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    The first International ReGenera R&D International for Aging Intervention and VCC Preventive Medical Promotion Foundation has been a flashy success.

    It has been held in Beijing last June 8, having as topics Gut Microbiota and Health. The keynote speaker was prof. Marotta and the meeting features the most authoritative Asian specialists in the field.

    The conference room was fully packed and, most important, about 10.000 physicians and health professionals registered for a live attendance at distance.

    The event as covered by the most reputed national TV channels and in the next days a series of interviews followed up.

    The organizer, VCC Preventive Medical Promotion Foundation, given this success, is planning further similar top scientific gatherings this year in other locations.

    There was a general consensus on the importance to deepen our knowledge in this area as well ass starting providing practical steps forwards an evaluation and phenotypic monitoring of gut microbiota, while envisaging designer pro-prebiotics interventions.

ANTI-INFLAMMATORY AND ANTI-MUTAGENIC EFFECT OF YHK PHYTOCOMPOUND IN HEPATOCYTES: IN VIEW OF AN AGE-MANAGEMENT LIVER PROTECTING APPROACH.

September 24, 2013

Zerbinati N, Marotta F, Nagpal R, Singh B, Mohania D, Milazzo M, Sapienza C, Italia A, Tomella C, Catanzaro R.

Abstract

RAGE regulates cellular proliferation in hepatocellular carcinoma (HCC) and the aim of this study was to test the in vitro effect of YHK, a nutraceutical with prior data suggesting its hepatocyte protecting role, in regulating RAGE in the proliferation of HCC cell line HuH7 as well checking also its potential modulation in the expression of the transcriptional factor NF-κB p65. Our study showed that YHK significantly reduced cellular growth in the HuH7 cell line (p<0.05). Moreover, this phytocompound partly reduced gene expression of NF-κB p65 (by 35%, p<0.05). These data suggest that YHK has a potential role as a modulator of RAGE and RAGE-ligands for potential healthy-liver intervention in HCC prevention strategies.

 

Rejuvenation Res. 2013 Sep 19. [Epub ahead of print]

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  • About ReGenera


    The first International ReGenera R&D International for Aging Intervention and VCC Preventive Medical Promotion Foundation has been a flashy success.

    It has been held in Beijing last June 8, having as topics Gut Microbiota and Health. The keynote speaker was prof. Marotta and the meeting features the most authoritative Asian specialists in the field.

    The conference room was fully packed and, most important, about 10.000 physicians and health professionals registered for a live attendance at distance.

    The event as covered by the most reputed national TV channels and in the next days a series of interviews followed up.

    The organizer, VCC Preventive Medical Promotion Foundation, given this success, is planning further similar top scientific gatherings this year in other locations.

    There was a general consensus on the importance to deepen our knowledge in this area as well ass starting providing practical steps forwards an evaluation and phenotypic monitoring of gut microbiota, while envisaging designer pro-prebiotics interventions.

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