• Home
  • About
  • Research
    • Founder
    • Round Table
    • Frontier Researchers/Clinicians
    • Scientific partners
  • CUTTING-EDGE MEETINGS
  • NOT TO MISS
  • Events & News
  • Videogallery
  • Contact Us
  • About Me


    The first International ReGenera R&D International for Aging Intervention and VCC Preventive Medical Promotion Foundation has been a flashy success.

    It has been held in Beijing last June 8, having as topics Gut Microbiota and Health. The keynote speaker was prof. Marotta and the meeting features the most authoritative Asian specialists in the field.

    The conference room was fully packed and, most important, about 10.000 physicians and health professionals registered for a live attendance at distance.

    The event as covered by the most reputed national TV channels and in the next days a series of interviews followed up.

    The organizer, VCC Preventive Medical Promotion Foundation, given this success, is planning further similar top scientific gatherings this year in other locations.

    There was a general consensus on the importance to deepen our knowledge in this area as well ass starting providing practical steps forwards an evaluation and phenotypic monitoring of gut microbiota, while envisaging designer pro-prebiotics interventions.

  • Home
  • About
  • Research
    • Founder
    • Round Table
    • Frontier Researchers/Clinicians
    • Scientific partners
  • CUTTING-EDGE MEETINGS
  • NOT TO MISS
  • Events & News
  • Videogallery
  • Contact Us

Effect of a fermented nutraceutical on thioredoxin level and TNF-alpha signalling in cirrhotic patients

May 20, 2011

J Biol Regul Homeost Agents. 2011 Jan-Mar;25(1):37-45.

Marotta F, Chui DH, Jain S, Polimeni A, Koike K, Zhou L, Lorenzetti A, Shimizu H, Yang H.

Source
ReGenera Research Group for Aging-Intervention, Milan, Italy.

Abstract
The aim of this study is to gain further insights into the possible nutraceutical effect on redox balance via thioredoxin (Trx) modulation and on the intrinsic susceptibility of monocytes to generate an inflammatory response. The study group consisted of thirty-two patients with compensated Child A-C, HCV-related cirrhosis. The patients were supplemented for 6 months with 6g/day of a certified fermented papaya preparation (FPP). Fifteen unsupplemented, age/gender-matched healthy subjects served as controls. The patients filled in a detailed diet-life style questionnaire, and blood samples were collected to test routine biochemistry, Trx, redox status (GSH, GSSG, GSH/GSSG ratio, 4-HNE and alpha-tocopherol). Moreover, isolated monocytes were tested for ex-vivo LPS-stimulated TNF-alpha production and TNF-alpha mRNA. As compared to control, patients with liver cirrhosis showed a significantly higher serum level of Trx. A significant correlation occurred with GSH/GSSG ratio in Child B and C patients. FPP supplementation brought about a significant reduction of Trx with levels comparable to the ones of healthy controls. Ten patients Child C (31.2 percent) showed borderline low levels of alpha-tocopherol while all cirrhotic patients, as a whole, showed a significantly abnormal redox balance. Supplementation with FPP did not modify alpha-tocopherol depletion but significantly improved redox balance parameters. Patients with liver cirrhosis showed a significantly upregulated TNF-alpha production in a time-dependent manner and this effect was more pronounced in more advanced stages of the disease and showed a significant correlation with alpha-tocopherol level. Supplementation with FPP significantly, although partially, downregulated TNF-alpha production from monocytes. Taken altogether, it would appear that the typical oxidative-inflammatory biochemical milieu of these patients is mirrored by a significant TNF-alpha upregulation at a monocyte level while a targeted nutraceutical might be a potentially amenable intervention to be part of validated scheduled treatments.

Share

Events & News

  • About ReGenera


    The first International ReGenera R&D International for Aging Intervention and VCC Preventive Medical Promotion Foundation has been a flashy success.

    It has been held in Beijing last June 8, having as topics Gut Microbiota and Health. The keynote speaker was prof. Marotta and the meeting features the most authoritative Asian specialists in the field.

    The conference room was fully packed and, most important, about 10.000 physicians and health professionals registered for a live attendance at distance.

    The event as covered by the most reputed national TV channels and in the next days a series of interviews followed up.

    The organizer, VCC Preventive Medical Promotion Foundation, given this success, is planning further similar top scientific gatherings this year in other locations.

    There was a general consensus on the importance to deepen our knowledge in this area as well ass starting providing practical steps forwards an evaluation and phenotypic monitoring of gut microbiota, while envisaging designer pro-prebiotics interventions.

  • Error: Please check if you enter Instagram username and Access Token in Theme Setting > Social Profiles
  • Follow Me On



    • Recent Posts

      • New Focus Area
        January 12, 2023
      • The Wellity Institute
        January 12, 2023
      • New Research Highlight
        September 16, 2021

    © 2019 by ReGenera R&D - Imternational for aging intervention