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    The first International ReGenera R&D International for Aging Intervention and VCC Preventive Medical Promotion Foundation has been a flashy success.

    It has been held in Beijing last June 8, having as topics Gut Microbiota and Health. The keynote speaker was prof. Marotta and the meeting features the most authoritative Asian specialists in the field.

    The conference room was fully packed and, most important, about 10.000 physicians and health professionals registered for a live attendance at distance.

    The event as covered by the most reputed national TV channels and in the next days a series of interviews followed up.

    The organizer, VCC Preventive Medical Promotion Foundation, given this success, is planning further similar top scientific gatherings this year in other locations.

    There was a general consensus on the importance to deepen our knowledge in this area as well ass starting providing practical steps forwards an evaluation and phenotypic monitoring of gut microbiota, while envisaging designer pro-prebiotics interventions.

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Intestinal immune-potentiation by a purified alkylglycerols compound

June 6, 2012

M.K. Kantah1 , H. Wakasugi 1 , A. Kumari 2 , P . Carrera-Bastos 3 , B. Palmieri 4 , Y. Naito5 , R. Catanzaro6 , R Kobayashi 1 , F.Marotta7

1 Suheiro Chem-Tech Center, Kumamoto, Japan;
2 Université du Québec, Institut National de la Recherche Scientifique, Centre Eau, Terre and Environnement, Québec, Canada,
3 Center for Primary Health Care Research, Faculty of Medicine, Lund University, Malmö, Sweden;
4 Dept. of Surgery, University of Modena, Italy;
5Immunology Research Center and Clinics, Nagoya, Japan;
6 Gastroenterology Unit, Dept. of Internal Medicine, University of Catania, Italy;
7 ReGenera Research Group for Aging Intervention,Milano, Italy

Abstract. Alkylglycerols have shown immune stimulant and adjuvant activity in several studies and the aim of the present research was to assess in particular the effect of shark liver-derived alkylglycerols on gut immune system. C57BL/6 mice, fed under specific pathogen free conditions, were randomly divided into two groups: a) fed normal laboratory food or b) added with alkylglycerols (2 mg/day/mouse) for 3 weeks. Intraepithelial lymphocytes (IEL) were retrieved from the small intestine and tested for NK and tumor cytotoxicity. Lymphocytes from liver, spleen and IEL were also assessed as for their counting and phenotypic characterization. Under supplementation with alkylglycerols, the number of lymphocytes yielded by the small intestine increased by to almost 40%.Moreover, the ratio of CD8αβ+ TCRαβ+ cells/CD8αα+ TCRαβ+ cells remarkably increased. In parallel with this reshaping in the distribution of lymphocyte subsets, tumor cytotoxicity of IEL against P815 cells and cytokine production from circulating lymphocytes were also en hanced. These data show that phylogenetically developed lymphocytes (CD8αβ+ , TCRαβ+ ) were signifi-
cantly activated by the oral administration of alkylglycerols. The present results indicate that purified alkylglycerols might have such significant potential via the enhancement of intestinal immunity, especially in the small intestine.(www.actabiomedica.it)

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    The first International ReGenera R&D International for Aging Intervention and VCC Preventive Medical Promotion Foundation has been a flashy success.

    It has been held in Beijing last June 8, having as topics Gut Microbiota and Health. The keynote speaker was prof. Marotta and the meeting features the most authoritative Asian specialists in the field.

    The conference room was fully packed and, most important, about 10.000 physicians and health professionals registered for a live attendance at distance.

    The event as covered by the most reputed national TV channels and in the next days a series of interviews followed up.

    The organizer, VCC Preventive Medical Promotion Foundation, given this success, is planning further similar top scientific gatherings this year in other locations.

    There was a general consensus on the importance to deepen our knowledge in this area as well ass starting providing practical steps forwards an evaluation and phenotypic monitoring of gut microbiota, while envisaging designer pro-prebiotics interventions.

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