• Home
  • About
  • Research
    • Founder
    • Round Table
    • Frontier Researchers/Clinicians
    • Scientific partners
  • CUTTING-EDGE MEETINGS
  • NOT TO MISS
  • Events & News
  • Videogallery
  • Contact Us
  • About Me


    The first International ReGenera R&D International for Aging Intervention and VCC Preventive Medical Promotion Foundation has been a flashy success.

    It has been held in Beijing last June 8, having as topics Gut Microbiota and Health. The keynote speaker was prof. Marotta and the meeting features the most authoritative Asian specialists in the field.

    The conference room was fully packed and, most important, about 10.000 physicians and health professionals registered for a live attendance at distance.

    The event as covered by the most reputed national TV channels and in the next days a series of interviews followed up.

    The organizer, VCC Preventive Medical Promotion Foundation, given this success, is planning further similar top scientific gatherings this year in other locations.

    There was a general consensus on the importance to deepen our knowledge in this area as well ass starting providing practical steps forwards an evaluation and phenotypic monitoring of gut microbiota, while envisaging designer pro-prebiotics interventions.

  • Home
  • About
  • Research
    • Founder
    • Round Table
    • Frontier Researchers/Clinicians
    • Scientific partners
  • CUTTING-EDGE MEETINGS
  • NOT TO MISS
  • Events & News
  • Videogallery
  • Contact Us

Microscopic and ultrastructural modifications of postmenopausal atrophic vaginal mucosa after fractional carbon dioxide laser treatment.

December 8, 2015
Zerbinati N1, Serati M, Origoni M, Candiani M, Iannitti T, Salvatore S, Marotta F, Calligaro A.

Author information

  • 1Department of Surgical and Morphological Sciences, University of Insubria, Varese, Italy.

Abstract

Vaginal atrophy occurring during menopause is closely related to the dramatic decrease in ovarian estrogens due to the loss of follicular activity. Particularly, significant changes occur in the structure of the vaginal mucosa, with consequent impairment of many physiological functions. In this study, carried out on bioptic vaginal mucosa samples from postmenopausal, nonestrogenized women, we present microscopic and ultrastructural modifications of vaginal mucosa following fractional carbon dioxide (CO2) laser treatment. We observed the restoration of the vaginal thick squamous stratified epithelium with a significant storage of glycogen in the epithelial cells and a high degree of glycogen-rich shedding cells at the epithelial surface. Moreover, in the connective tissue constituting the lamina propria, active fibroblasts synthesized new components of the extracellular matrix including collagen and ground substance (extrafibrillar matrix) molecules. Differently from atrophic mucosa, newly-formed papillae of connective tissue indented in the epithelium and typical blood capillaries penetrating inside the papillae, were also observed. Our morphological findings support the effectiveness of fractional CO2 laser application for the restoration of vaginal mucosa structure and related physiological trophism. These findings clearly coupled with striking clinical relief from symptoms suffered by the patients before treatment.

PMID:
25410301
[PubMed – in process]
Share

Events & News

  • About ReGenera


    The first International ReGenera R&D International for Aging Intervention and VCC Preventive Medical Promotion Foundation has been a flashy success.

    It has been held in Beijing last June 8, having as topics Gut Microbiota and Health. The keynote speaker was prof. Marotta and the meeting features the most authoritative Asian specialists in the field.

    The conference room was fully packed and, most important, about 10.000 physicians and health professionals registered for a live attendance at distance.

    The event as covered by the most reputed national TV channels and in the next days a series of interviews followed up.

    The organizer, VCC Preventive Medical Promotion Foundation, given this success, is planning further similar top scientific gatherings this year in other locations.

    There was a general consensus on the importance to deepen our knowledge in this area as well ass starting providing practical steps forwards an evaluation and phenotypic monitoring of gut microbiota, while envisaging designer pro-prebiotics interventions.

  • Error: Please check if you enter Instagram username and Access Token in Theme Setting > Social Profiles
  • Follow Me On



    • Recent Posts

      • New Focus Area
        January 12, 2023
      • The Wellity Institute
        January 12, 2023
      • New Research Highlight
        September 16, 2021

    © 2019 by ReGenera R&D - Imternational for aging intervention